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1: Title: Integration of chemical and RNAi multiparametric profiles identifies triggers of intracellular mycobacterial killing.
Journal: Cell host & microbe (Cell Host Microbe), Vol. 13 (2): 129-42, 2013 .
Snippet: We designed a quantitative multiparametric image-based assay to measure intracellular mycobacteria in primary human macrophages, screened a chemical library containing FDA-approved drugs, and validated three compounds for intracellular killing of M. tuberculosis.
Affiliation: Max-Planck Institute of Molecular Cell Biology and Genetics, 108 Pfotenhauerstrasse, 01307 Dresden, Germany. .
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